In multiple sclerosis, Alzheimer’s disease, and other neurological diseases, vascular leakage is known to occur but its causation is still in question. Previous work has shown the importance of fibrin in this process. Katerina Akassoglou, Ph.D. discussed with attendees at Wednesday’s State-of-the-Art Session her group’s research evaluating fibrin in neurological diseases.
Her studies demonstrated that fibrin in the brain induces microglia activation and pro-inflammatory gene expression, promotes axonal damage and oxidative stress, indices peripheral macrophage recruitment.
These findings suggest that fibrin is a potential target for drug development and intervention in some neurological diseases.