An impressive and growing body of literature indicates that there is a bidirectional relationship between the immune and hemostatic systems.
The ISTH open access journal, Research and Practice in Thrombosis and Haemostasis (RPTH), invited the ISTH 2021 Virtual Congress State-of-the-Art (SOA) speakers to submit Illustrated Capsules featuring the defining science of their presentation.
Activated platelets are thought to provide the majority of procoagulant PS, whose externalization is regulated by the phospholipid scramblase transmembrane protein 16F (TMEM16F). This was one of the goals of the research presented by Alec Schmaier, M.D., Ph.D.
On Sunday, July 18, 2021, Cara Sake of the Colorado School of Mines presented results from research aimed at generating the first metabolic flux map of resting and thrombin-activated platelets based on intracellular isotope profiling.
Evidence suggests that DTRI-177 may allosterically modulate IXa function and also possibly interfere with the IXa/VIIIa interaction within intrinsic Xase, but this is still unknown.