Daily Highlights

FXa Inhibitors Target FXa-PAR2 Signaling

A balanced coagulation pathway represents an equilibrium between the procoagulant pathway that is responsible for clot formation in response to vessel injury and mechanisms that inhibit clot extension beyond the injury site. Moreover, coagulation also limits infections and is therefore connected with immunity.

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Safe Anticoagulants: Targeting the Contact Pathway

The contact system contains a series of proteases and cofactors that assemble on cardiovascular cells, platelets, and other inflammatory cells. This system has not been appreciated historically because deficiencies of contact system proteins were not known to be associated with bleeding disorders.

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Microbiota and Cardiovascular Risk

The gut microbiota is an environmental factor that impacts vascular physiology, locally in the intestine, but also through remote signaling. Dependent on diet, numerous mouse studies demonstrated that this gut-resident microbial ecosystem affects atherogenesis.

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