Both α- and γ-Chain Crosslinks Mediated by FXIIIa Affect Fibrin Fiber Resistance to Rupture

Timea Feller, Ph.D.
University of Leeds
Leeds, U.K.

Mechanical strength of individual fibrin fibers prevents clot breakdown and subsequent embolism. The effect of γ-chain crosslinking of fibrin in reducing pulmonary embolism was shown in this study. Timea Feller, M.D., further discusses the investigation of how α-crosslinks alter the mechanical behavior of fibrin fibers. Atomic force microscopy coupled with fluorescence microscopy was used to study the stress-strain behavior of each individual fibrin fiber. Fiber characteristics were defined and compared to wild type counterparts. Key biomechanical properties of fibrin fibers for the prevention of clot embolism were elaborated using the data extracted. Fibers in the absence of both α- and γ-chain crosslinks were more prone to rupture, indicating their key role in the prevention of embolism.

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